The healthcare system in Latin America (LATAM) has made significant improvements in the last few decades. Nevertheless, it still faces significant challenges, including poor access to healthcare services, insufficient resources, and inequalities in health that may lead to decreased life expectancy, lower quality of life, and poor economic growth. Digital Healthcare (DH) enables the convergence of innovative technology with recent advances in neuroscience, medicine, and public healthcare policy.a In this article, we discuss key DH efforts that can help address some of the challenges of the healthcare system in LATAM focusing on two countries: Brazil and Mexico. We chose to study DH in the context of Brazil and Mexico as both countries are good representatives of the situation of the healthcare system in LATAM and face similar challenges along with other LATAM countries. Brazil and Mexico have the largest economies in the region and account for approximately half of the population and geographic territory of LATAM.11